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<div class="HwContainer HwElement" id="HwContainer"><a class="HwMainSkipNavigation" href="#HwContentTitle"><span class="HwAccessibilityText">Skip Navigation</span></a><div class="HwBlock" id="HwMain" role="main"><div class="HwRow"><div class="HwColumn" id="HwColumnSidebar1"><div class="HwCustom" id="HwCustomSidebar"> </div></div><div class="HwColumn" id="HwColumnContent"><div id="HwContentTop"> </div><div class="HwTypeMedicalTest HwContentWrapper HwElement" role="article" id="HwContentWrapper"><div class="HwCustom" id="HwCustomContentTop"> </div><div class="HwContentHeader"><p><a name="top" id="Hwtop"><span class="HwAccessibilityText">Top of the page</span></a> </p></div><div class="HwContentTitle"><h1 id="HwContentTitle" tabindex="-1">Cell-Free DNA Test</h1></div><div class="HwContentTopNavigation"> </div><div class="HwContent"><div class="HwNavigationSection HwSectionSpecialSection" id="sec-abp6916"><h2 class="HwSectionTitle" fingerprint="d4032d6d" fingerprint-exact="4fcae40e">Test Overview</h2> <p fingerprint="98f294e8" fingerprint-exact="3ca9092a">Cell-free fetal DNA is a screening test to look for certain birth defects in a <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="stf124121" data-hw-section="stf124121-sec" rel="Definition" hw:document-type="Definition" hw:document-href="stf124121" data-hwid="stf124121" hw:section-href="stf124121-sec" href="?id=stf124121#stf124121-sec"><span class="HwLinkText">fetus</span></a>. It's done to find birth defects caused by an abnormal number of <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="stc123678" data-hw-section="stc123678-sec" rel="Definition" hw:document-type="Definition" hw:document-href="stc123678" data-hwid="stc123678" hw:section-href="stc123678-sec" href="?id=stc123678#stc123678-sec"><span class="HwLinkText">chromosomes</span></a>. It also can reveal the sex and blood type of the fetus. </p> <p fingerprint="eef97194" fingerprint-exact="bff8b09a">This is a blood test for the mother. The test can be done as early as 10 weeks in the pregnancy. </p> <p fingerprint="d362b21c" fingerprint-exact="d8312e33">If this screening test is positive, it means there is a chance your baby has a birth defect. In that case, your doctor may suggest that you have a diagnostic test, which can show if there is a birth defect. </p> </div><div class="HwNavigationSection HwSectionSpecialSection" id="sec-abp6917"><h2 class="HwSectionTitle" fingerprint="3d5095ef" fingerprint-exact="55cd7304">Why It Is Done</h2> <p fingerprint="649de942" fingerprint-exact="cb0064a9">The test is used to look for birth defects caused by too many or too few chromosomes, such as <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="bg1006" data-hw-section="bg1006-sec" rel="Definition" hw:document-type="Definition" hw:document-href="bg1006" data-hwid="bg1006" hw:section-href="bg1006-sec" href="?id=bg1006#bg1006-sec"><span class="HwLinkText">trisomy 18</span></a> and <a class="HwLinkDefinition" data-hw-type="Definition" data-hw-document-href="std120885" data-hw-section="std120885-sec" rel="Definition" hw:document-type="Definition" hw:document-href="std120885" data-hwid="std120885" hw:section-href="std120885-sec" href="?id=std120885#std120885-sec"><span class="HwLinkText">Down syndrome (trisomy 21)</span></a>.</p> </div><div class="HwNavigationSection HwSectionSpecialSection" id="sec-abp6918"><h2 class="HwSectionTitle" fingerprint="026e985e" fingerprint-exact="df1d0bbc">How To Prepare</h2> <p fingerprint="0c7dd686" fingerprint-exact="2a50b250">In general, there's nothing you have to do before this test, unless your doctor tells you to.</p> </div><div class="HwNavigationSection HwSectionSpecialSection" id="sec-abp6919"><h2 class="HwSectionTitle" fingerprint="e59ce77f" fingerprint-exact="42dd83e2">How It Is Done</h2> <p fingerprint="5aae0cd8" fingerprint-exact="a27baf64">A health professional uses a needle to take a blood sample, usually from the arm.</p> <h3 class="HwSubSectionTitle" fingerprint="ffd3beac" fingerprint-exact="500b4a26">Watch</h3> <div class="HwOptionalAll"> <div class="hwMediaLinks"> <ul fingerprint="2a924914" fingerprint-exact="939aff65"> <li class="HwOptionalAny"> <a class="HwLinkMultiMedia" data-hw-type="MultiMedia" data-hw-document-href="acj1944" data-hw-section="acj1944-sec" rel="MultiMedia" hw:document-type="MultiMedia" hw:document-href="acj1944" data-hwid="acj1944" hw:section-href="acj1944-sec" hw:link-type="video" href="?id=acj1944#acj1944-sec"><span class="HwLinkText">Learning About Your Blood Test</span><br><img class="HwMediaImage" data-hw-resource-path="media/thumbnails/acj1944_416x312.jpg" hw:resource-path="media/thumbnails/acj1944_416x312.jpg" src="https://ixbapi.healthwise.net/Resource/14.3/en-us/media/thumbnails/acj1944_416x312.jpg" width="416" height="312" alt hw:release-quarter="14.3"></a> </li> <li class="HwOptionalAny"> <a class="HwLinkMultiMedia" data-hw-type="MultiMedia" data-hw-document-href="aci5157" data-hw-section="aci5157-sec" rel="MultiMedia" hw:document-type="MultiMedia" hw:document-href="aci5157" data-hwid="aci5157" hw:section-href="aci5157-sec" hw:link-type="video" href="?id=aci5157#aci5157-sec"><span class="HwLinkText">Learning About Blood Tests for Children</span><br><img class="HwMediaImage" data-hw-resource-path="media/thumbnails/aci5157_416x312.jpg" hw:resource-path="media/thumbnails/aci5157_416x312.jpg" src="https://ixbapi.healthwise.net/Resource/14.3/en-us/media/thumbnails/aci5157_416x312.jpg" width="416" height="312" alt hw:release-quarter="14.3"></a> </li> </ul> </div> </div> </div><div class="HwNavigationSection HwSectionSpecialSection" id="sec-abp6920"><h2 class="HwSectionTitle" fingerprint="2dd5db50" fingerprint-exact="deba34d5">How It Feels</h2> <p fingerprint="1ac94c75" fingerprint-exact="5d3995d8">When a blood sample is taken, you may feel nothing at all from the needle. Or you might feel a quick sting or pinch.</p> </div><div class="HwNavigationSection HwSectionSpecialSection" id="sec-abp6921"><h2 class="HwSectionTitle" fingerprint="a566bce5" fingerprint-exact="1aacb8d8">Risks</h2> <p fingerprint="f81952f3" fingerprint-exact="73b0e5b4">There is very little chance of having a problem from this test. When a blood sample is taken, a small bruise may form at the site.</p> </div><div class="HwNavigationSection HwSectionSpecialSection" id="sec-abp6922"><h2 class="HwSectionTitle" fingerprint="9413e669" fingerprint-exact="9fa3e414">Results</h2> <p fingerprint="e80e536c" fingerprint-exact="10736359">The fetal DNA will be looked at to see if there are missing or extra chromosomes. If there is an extra or missing chromosome (a positive result), your baby may have a chromosomal birth defect. A negative result means that your baby is unlikely to have one of the birth defects this test looks for. </p> <p fingerprint="151b1b9e" fingerprint-exact="9c516682">This test can find up to 99% of trisomies such as 18 and 21. That means that it will find these birth defects up to 99 times out of 100 and won't find them 1 time out of 100.<sup class="Reference"><a class="HwLinkReference" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6915-Bib" rel="cite1-Cit" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6915-Bib" hw:name-href="cite1" href="?id=abp6915#abp6915-Bib"><span class="HwAccessibilityText">footnote </span>1</a></sup></p> </div><div class="HwNavigationSection HwSectionRelatedInformation" id="sec-abp6915-RelInfo"><h2 class="HwSectionTitle" fingerprint="d5f858e0" fingerprint-exact="c0ffe04b">Related Information</h2><ul fingerprint="84fa2609" fingerprint-exact="ec8cccf3"><li class="HwOptionalAny"><a data-hw-type="Focus" data-hw-document-href="zm2257" data-hw-section="zm2257-sec" hw:document-type="Focus" hw:document-href="zm2257" data-hwid="zm2257" hw:section-href="zm2257-sec" href="?id=zm2257#zm2257-sec">Medical Tests: Questions to Ask the Doctor</a></li></ul></div><div class="HwNavigationSection HwSectionReferences" id="sec-abp6915-Bib"><h2 class="HwSectionTitle">References</h2> <blockquote> <h3 class="HwSubSectionTitle">Citations</h3> <ol> <li> <a name="cite1"> </a>American College of Obstetricians and Gynecologists (2016). Screening for fetal aneuploidy. ACOG Practice Bulletin No. 163. <i>Obstetrics and Gynecology</i>, 127(5): e123–e137. DOI: 10.1097/AOG.0000000000001406. Accessed April 6, 2017.</li> </ol> </blockquote> </div><div class="HwNavigationSection HwCreditsSection HwSectionCredits" id="sec-abp6915-Credits"><h2 class="HwSectionTitle">Credits</h2><div class="HwContentInformation"><div class="HwLastUpdated"><p><span class="HwInfoLabel">Current as of: </span> April 30, 2024</p></div><div class="HwCredits"><p><span class="HwInfoLabel">Author: </span><a class="HwLinkExternal" href="https://www.healthwise.org/specialpages/legal/abouthw/en" title="Opens in a new window"><span class="HwLinkText">Ignite Healthwise, LLC Staff</span></a><br><span><b><a class="HwLinkExternal" href="https://www.healthwise.org/specialpages/legal/abouthw/en" title="Opens in a new window"><span class="HwLinkText">Clinical Review Board</span></a></b></span><br>All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.</p></div></div></div></div><div class="HwCustom" id="HwCustomContentBottom"> </div><div class="HwContentNavigation"><div class="HwSectionNavItem" style="display:block" id="secNav-abp6916"><div class="HwContentNavigationNone"> </div><div class="HwContentNavigationTop"><a href="#top">Top of the page</a></div><div class="HwContentNavigationNext"><p>Next Section: </p><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6917" id="nextLink-abp6917" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6917" href="?id=abp6915#abp6917">Why It Is Done</a><span class="HwNavLinkArrow" aria-hidden="true"> »</span></div><div class="HwClear"> </div></div><div class="HwSectionNavItem" style="display:none" id="secNav-abp6917"><div class="HwContentNavigationPrev"><p>Previous Section: </p><span class="HwNavLinkArrow" aria-hidden="true">« </span><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6916" 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data-hw-section="abp6915-RelInfo" id="prevLink-abp6915-RelInfo" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6915-RelInfo" href="?id=abp6915#abp6915-RelInfo">Related Information</a></div><div class="HwContentNavigationTop"><a href="#top">Top of the page</a></div><div class="HwContentNavigationNext"><p>Next Section: </p><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6915-Credits" id="nextLink-abp6915-Credits" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6915-Credits" href="?id=abp6915#abp6915-Credits">Credits</a><span class="HwNavLinkArrow" aria-hidden="true"> »</span></div><div class="HwClear"> </div></div><div class="HwSectionNavItem" style="display:none" id="secNav-abp6915-Credits"><div class="HwContentNavigationPrev"><p>Previous Section: </p><span class="HwNavLinkArrow" aria-hidden="true">« </span><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6915-Bib" id="prevLink-abp6915-Bib" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6915-Bib" href="?id=abp6915#abp6915-Bib">References</a></div><div class="HwContentNavigationTop"><a href="#top">Top of the page</a></div><div class="HwContentNavigationNone"> </div><div class="HwClear"> </div></div></div><div class="HwContentInformation"><div class="HwLastUpdated"><p><span class="HwInfoLabel">Current as of: </span>April 30, 2024</p></div><div class="HwCredits"><p><span class="HwInfoLabel">Author: </span><a class="HwLinkDisclaimer" href="https://www.healthwise.org/specialpages/legal/abouthw/en">Ignite Healthwise, LLC Staff</a></p><p><a class="HwLinkDisclaimer" href="https://www.healthwise.org/specialpages/legal/abouthw/en"><span><b>Clinical Review Board</b></span></a><br>All Healthwise education is reviewed by a team that includes physicians, nurses, advanced practitioners, registered dieticians, and other healthcare professionals.</p></div></div><div class="HwCitations" style="display:none;"><div class="HwCitation" id="cite1-Cit">American College of Obstetricians and Gynecologists (2016). Screening for fetal aneuploidy. ACOG Practice Bulletin No. 163. <i>Obstetrics and Gynecology</i>, 127(5): e123–e137. DOI: 10.1097/AOG.0000000000001406. Accessed April 6, 2017.</div></div></div></div><div class="HwColumn" id="HwColumnSidebar2"><div class="HwCustom" id="HwCustomNavigationTop"> </div><div class="HwElement" id="HwNavigationWrapper"><div class="HwNavigation" id="HwNavigation" role="navigation"><h3 class="HwNavStackHeader" id="HwNavStackHeader">Topic Contents</h3><ul aria-labelledby="HwNavStackHeader"><li id="nav-abp6916"><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6916" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6916" href="?id=abp6915#abp6916">Test Overview</a></li><li id="nav-abp6917"><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6917" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6917" href="?id=abp6915#abp6917">Why It Is Done</a></li><li id="nav-abp6918"><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6918" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6918" href="?id=abp6915#abp6918">How To Prepare</a></li><li id="nav-abp6919"><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6919" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6919" href="?id=abp6915#abp6919">How It Is Done</a></li><li id="nav-abp6920"><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6920" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6920" href="?id=abp6915#abp6920">How It Feels</a></li><li id="nav-abp6921"><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6921" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6921" href="?id=abp6915#abp6921">Risks</a></li><li id="nav-abp6922"><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6922" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6922" href="?id=abp6915#abp6922">Results</a></li><li id="nav-abp6915-RelInfo"><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6915-RelInfo" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6915-RelInfo" href="?id=abp6915#abp6915-RelInfo">Related Information</a></li><li id="nav-abp6915-Bib"><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6915-Bib" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6915-Bib" href="?id=abp6915#abp6915-Bib">References</a></li><li id="nav-abp6915-Credits"><a class="HwLinkNavstack" data-hw-type="MedicalTest" data-hw-document-href="abp6915" data-hw-section="abp6915-Credits" hw:document-type="MedicalTest" hw:document-href="abp6915" data-hwid="abp6915" hw:section-href="abp6915-Credits" href="?id=abp6915#abp6915-Credits">Credits</a></li></ul></div></div><div class="HwNavigationWrapper HwNavigationEmpty"> </div><div class="HwCustom" id="HwCustomNavigationBottom"> </div></div></div></div><div class="HwBlock" id="HwFooter"><div class="HwRow"><div class="HwCustom HwColumn" id="HwCustomFooterLeft"> </div><div class="HwColumn" id="HwFooterLegal"><div class="HwLegal HwElement" role="contentinfo"><div class="HwLogo"><a class="HwLinkExternal" href="https://www.healthwise.org/specialpages/legal/abouthw/en"><img class="HwNoHcMode" data-hw-resource-path="media/interface/hwlogo.png" alt="Click here to learn about Ignite Healthwise, LLC" src="https://ixbapi.healthwise.net/Resource/14.3/en-us/media/interface/hwlogo.png" hw:resource-path="media/interface/hwlogo.png" hw:release-quarter="14.3"><img class="HwHcMode" data-hw-resource-path="media/interface/hwlogo_hc.png" alt="Click here to learn about Ignite Healthwise, LLC" src="https://ixbapi.healthwise.net/Resource/14.3/en-us/media/interface/hwlogo_hc.png" hw:resource-path="media/interface/hwlogo_hc.png" hw:release-quarter="14.3"></a></div><div class="HwDisclaimer"><p>This information does not replace the advice of a doctor. 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